A principle diterpenoid isolated from A. paniculata that inhibits LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM); reduces VEGF-induced proliferation of HUVECs; inhibits furin with an IC50 value of 53.5 µM

Neoandrographolide – 1 mg

Brand:
Cayman
CAS:
27215-14-1
Storage:
-20
UN-No:
Non-Hazardous - /

Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia. Extracts from A. paniculata have been reported to exert a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.{21112} Neoandrographolide has been shown to inhibit LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM).{28493} At 25 µM, it can reduce VEGF-induced proliferation of human umbilical vein endothelial cells.{28494} Neoandrographolide also inhibits the pro-protein convertase furin with an IC50 value of 53.5 µM.{28495}  

 

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SKU: 11742 - 1 mg Category:

Description

A principle diterpenoid isolated from A. paniculata that inhibits LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC50 = 35.5 µM); reduces VEGF-induced proliferation of HUVECs; inhibits furin with an IC50 value of 53.5 µM

Formal name: 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone

Synonyms: 

Molecular weight: 480.6

CAS: 27215-14-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases

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