An antipsychotic that binds D2-like receptors preferentially over D1-like receptors (Kis = 0.06

Nemonapride – 10 mg

Brand:
Cayman
CAS:
75272-39-8
Storage:
-20
UN-No:
Non-Hazardous - /

Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.{34046} It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively).{34046,32473} Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).{34047,34045}  

 

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Description

An antipsychotic that binds D2-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively); also binds σ1 and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the 5-HT1A receptor (IC50 = 34 nM)

Formal name: rel-5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-benzamide

Synonyms:  YM-09151-2

Molecular weight: 387.9

CAS: 75272-39-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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