An L-type calcium channel blocker; induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19; inhibits L-type calcium channels in chick ciliary neurons; increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells; decreases Survivin expression in A549 cells

Nemadipine A – 25 mg

Brand:
Cayman
CAS:
54280-71-6
Storage:
-20
UN-No:
Non-Hazardous - /

Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome.{38802} It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells.{38803} It also decreases Survivin expression when used alone or in combination with TRAIL in A549 cells.  

 

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Description

An L-type calcium channel blocker; induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19; inhibits L-type calcium channels in chick ciliary neurons; increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells; decreases Survivin expression in A549 cells,

Formal name: 1,4-dihydro-2,6-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester

Synonyms: 

Molecular weight: 419.3

CAS: 54280-71-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cancer|Cell Death|Apoptosis

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