An orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM) that is used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection

Nelfinavir (mesylate) – 5 mg

Brand:
Cayman
CAS:
159989-65-8
Storage:
-20
UN-No:
Non-Hazardous - /

Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM).{24362} It demonstrates anti-cancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 μM).{24361} Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.  

 

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Description

An orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM) that is used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection

Formal name: (3S,4aS,8aS)-N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide, monomethanesulfonate

Synonyms:  AG-1343|Nelfin

Molecular weight: 663.9

CAS: 159989-65-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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