A purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies

Nelarabine – 5 mg

Brand:
Cayman
CAS:
121032-29-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Nelarabine is a purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies.{23725} Nelarabine is converted into arabinosyl-guanine (ara-G) in the blood, and ara-G is selectively accumulated in T cells and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into DNA.{32257,32256} This leads to DNA breaks, increased expression of Fas ligand, and apoptosis.{23725,32256} Ara-G is accumulated most effectively by acute lymphoid leukemia and chronic myeloid leukemia blasts.{23725}  

 

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Description

A purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies

Formal name: 9-β-D-arabinofuranosyl-6-methoxy-9H-purin-2-amine

Synonyms:  GW 506U78|Nelzarabine

Molecular weight: 297.3

CAS: 121032-29-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair

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