A mast cell stabilizer; inhibits IgE-induced histamine release from MC/3T3 cells preincubated with IL-2 at 10 µM; prevents early- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin; prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis at 2 mg/kg

Nedocromil (sodium salt) – 50 mg

Brand:
Cayman
CAS:
69049-74-7
Storage:
-20
UN-No:
Non-Hazardous - /

Nedocromil is a mast cell stabilizer.{42511} It inhibits IgE-induced histamine release from rat peritoneal mast cells cocultured with 3T3 cells (MC/3T3) and preincubated with IL-2 when used at a concentration of 10 µM in acute (1 hour) and chronic (5 days) assays. Nedocromil prevents early- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin.{42512} It also prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis when administered intravenously at a dose of 2 mg/kg.{42513} Formulations containing nedocromil have been used in the treatment of allergic conjunctivitis and asthma.  

 

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SKU: 24005 - 50 mg Category:

Description

A mast cell stabilizer; inhibits IgE-induced histamine release from MC/3T3 cells preincubated with IL-2 at 10 µM; prevents early- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin; prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis at 2 mg/kg

Formal name: 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, disodium salt

Synonyms: 

Molecular weight: 415.3

CAS: 69049-74-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma

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