An anticancer agent; inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cancer cells (IC50s = 4.6 and 3.4 μM

Nedaplatin – 50 mg

Brand:
Cayman
CAS:
95734-82-0
Storage:
-20
UN-No:
Non-Hazardous - /

Nedaplatin is a derivative of cisplatin (Item No. 13119) with anticancer activity.{48686} Nedaplatin undergoes spontaneous hydrolysis to form platinum complexes that cross-link DNA resulting in apoptosis and cell death.{48683,48684} It inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cells (IC50s = 4.6 and 3.4 μM, respectively) and inhibits S to G2 and G2/M to G1 cell cycle progression.{48685} Nedaplatin (44 mg/kg) decreases tumor volume and increases survival in a Lewis lung carcinoma syngeneic mouse model.{48686} Nedaplatin (40 mg/kg) also decreases tumor volume in an HNC-3 head and neck cancer mouse xenograft model.{48687} It exhibits reduced nephrotoxicity in rats compared with cisplatin.{48684}  

 

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Description

An anticancer agent; inhibits the growth of human NUGC-4 gastric and KSE-1 esophageal squamous carcinoma cancer cells (IC50s = 4.6 and 3.4 μM, respectively); inhibits S to G2 and G2/M to G1 cell cycle progression; decreases tumor volume and increases survival in a Lewis lung carcinoma mouse model at 44 mg/kg; decreases tumor volume in an HNC-3 head and neck cancer xenograft mouse model at 40 mg/kg; exhibits reduced nephrotoxicity in rats compared with cisplatin

Formal name: (SP-4-3)-diammine[2-(hydroxy-κO)acetato(2-)-κO]-platinum

Synonyms:  NSC 375101

Molecular weight: 303.2

CAS: 95734-82-0

Purity: ≥95%

Formulation: A crystalline solid

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