Inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM; structurally and biologically distinct from other necrostatins as it does not inhibit RIP1 kinase

Necrostatin-7 – 25 mg

Brand:
Cayman
CAS:
351062-08-3
Storage:
-20
UN-No:
Non-Hazardous - /

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-α (TNF-α) induced necrosis.{20737} Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM.{20735}  

 

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SKU: 10528 - 25 mg Category:

Description

Inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM; structurally and biologically distinct from other necrostatins as it does not inhibit RIP1 kinase

Formal name: 5-((3-(4-fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one

Synonyms:  Nec-7

Molecular weight: 371.4

CAS: 351062-08-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Death|Necroptosis

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