An inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM

Necrostatin-1 – 10 mg

Brand:
Cayman
CAS:
4311-88-0
Storage:
-20
UN-No:
Non-Hazardous - /

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-α (TNF-α) induced necrosis.{20737} Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM.{20736,20737} It has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.{20736,20737}  

 

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SKU: 11658 - 10 mg Category:

Description

An inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM

Formal name: 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

Synonyms:  Nec-1

Molecular weight: 259.3

CAS: 4311-88-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cell Biology|Cell Death|Necroptosis||Research Area|Cell Biology|Cell Signaling

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