A purine ribonucleoside with diverse biological activities; reduces HSV-1 viral plaque formation in Vero cells (IC50 = 0.6 µM); active against M. phlei

Nebularine – 25 mg

Brand:
Cayman
CAS:
550-33-4
Storage:
-20
UN-No:
Non-Hazardous - /

Nebularine is a purine ribonucleoside and an adenosine analog that has been found in L. nebularis and has diverse biological activities.{52765,52766,52767,52768,23726} It reduces herpes simplex virus 1 (HSV-1) viral plaque formation in Vero cells (IC50 = 0.6 µM) and is active against M. phlei, M. avium, M. tuberculosis, and B. abortus.{52765,52766} Nebularine (10 and 100 µM) is cytotoxic to COS-7 cells and induces pyknosis in mouse sarcoma 180 cells and mouse embryonic skin explants in a concentration-dependent manner.{52767,52768} It inhibits root growth of wheat seedlings when used at concentrations ranging from 0.1 to 2 mM.{52766} Nebularine also inhibits adenosine deaminase (Ki = 16 µM).{23726}  

 

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SKU: 31329 - 25 mg Category:

Description

A purine ribonucleoside with diverse biological activities; reduces HSV-1 viral plaque formation in Vero cells (IC50 = 0.6 µM); active against M. phlei, M. avium, M. tuberculosis, and B. abortus; cytotoxic to COS-7 cells at 10 and 100 µM; induces pyknosis in mouse sarcoma 180 cells and mouse embryonic skin explants; inhibits root growth of wheat seedlings from 0.1-2 mM; inhibits adenosine deaminase (Ki = 16 µM)

Formal name: 9-β-D-ribofuranosyl-9H-purine

Synonyms:  Desaminoadenosine|NSC 65423|Purine riboside|Purinosine|Ribosylpurine

Molecular weight: 252.2

CAS: 550-33-4

Purity: ≥98%

Formulation: A crystalline solid

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