Description
A derivative of salicylanilide with anti-inflammatory activities; inhibits RANKL-induced osteoclast differentiation of BMDMs and RAW 264.7 cells at 10 and 15 µM; decreases RANKL-induced expression of the osteoclastogenic genes Nfatc1, Acp5, Ctsk, Oscar, Itgb3, and Dcstamp in BMDMs and inhibits phosphorylation of IĸB and nuclear translocation of NF-ĸB in RANKL-stimulated RAW 264.7 cells at 15 µM; reduces collagen-induced increases in the serum levels of TNF-α and IL-1β, as well as the numbers of osteoclasts and histological severity of bone erosion, cartilage damage, and synovial inflammation in joints in a mouse model of arthritis at 62.5 mg/kg
Formal name: N-(4-chloro-2-fluorophenyl)-2-hydroxy-benzamide
Synonyms:
Molecular weight: 265.7
CAS: 1308631-40-4
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity
