A derivative of salicylanilide with anti-inflammatory activities; inhibits RANKL-induced osteoclast differentiation of BMDMs and RAW 264.7 cells at 10 and 15 µM; decreases RANKL-induced expression of the osteoclastogenic genes Nfatc1

NDMC101 – 10 mg

Brand:
Cayman
CAS:
1308631-40-4
Storage:
-20
UN-No:
Non-Hazardous - /

NDMC101 is a derivative of salicylanilide with anti-inflammatory activities.{52043} It inhibits RANKL-induced osteoclast differentiation of bone marrow-derived macrophages (BMDMs) and RAW 264.7 cells when used at concentrations of 10 and 15 µM. NDMC101 (15 µM) decreases RANKL-induced expression of the osteoclastogenic genes Nfatc1, Acp5, Ctsk, Oscar, Itgb3, and Dcstamp in BMDMs and inhibits phosphorylation of IĸB and nuclear translocation of NF-ĸB in RANKL-stimulated RAW 264.7 cells. It reduces collagen-induced increases in the serum levels of TNF-α and IL-1β, as well as the numbers of osteoclasts and histological severity of bone erosion, cartilage damage, and synovial inflammation in joints in a mouse model of arthritis when used at a concentration of 62.5 mg/kg.  

 

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Description

A derivative of salicylanilide with anti-inflammatory activities; inhibits RANKL-induced osteoclast differentiation of BMDMs and RAW 264.7 cells at 10 and 15 µM; decreases RANKL-induced expression of the osteoclastogenic genes Nfatc1, Acp5, Ctsk, Oscar, Itgb3, and Dcstamp in BMDMs and inhibits phosphorylation of IĸB and nuclear translocation of NF-ĸB in RANKL-stimulated RAW 264.7 cells at 15 µM; reduces collagen-induced increases in the serum levels of TNF-α and IL-1β, as well as the numbers of osteoclasts and histological severity of bone erosion, cartilage damage, and synovial inflammation in joints in a mouse model of arthritis at 62.5 mg/kg

Formal name: N-(4-chloro-2-fluorophenyl)-2-hydroxy-benzamide

Synonyms: 

Molecular weight: 265.7

CAS: 1308631-40-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity

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