An inhibitor of ACC1 and ACC2 (IC50s = 2.1 and 6.1 nM

ND-630 – 1 mg

Brand:
Cayman
CAS:
1434635-54-7
Storage:
-20
UN-No:
Non-Hazardous - /

ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes).{38875} It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 µM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.  

 

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SKU: 23961 - 1 mg Category:

Description

An inhibitor of ACC1 and ACC2 (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes); inhibits ACC dimerization; selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 µM; reduces fatty acid synthesis in HepG2 cells (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively); reduces hepatic steatosis, improves glucose-stimulated insulin secretion, and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats

Formal name: 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-thieno[2,3-d]pyrimidine-3(2H)-acetic acid

Synonyms:  Firsocostat|GS-0976

Molecular weight: 569.6

CAS: 1434635-54-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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