An HDAC inhibitor (IC50s = 48

NCH-51 – 10 mg

Brand:
Cayman
CAS:
848354-66-5
Storage:
-20
UN-No:
Non-Hazardous - /

NCH-51 is an inhibitor of histone deacetylases (HDACs) with IC50 values of 48, 32, and 41 nM for HDAC1, 4, and 6, respectively.{41830} It increases acetylation of histone H4 and α-tubulin in HCT116 cells when used at concentrations ranging from 1 to 25 µM and inhibits the growth of a variety of cancer cell lines (EC50s = 1.1-9.1 µM).{41831,41832} NCH-51 (0.4-1.6 µM) also induces HIV-1 viral replication in OM10.1 and ACH-2 cells latently infected with HIV-1 when used alone and, to a greater effect, when used in the presence of TNF-α, with cytotoxic concentration (CC50) values of approximately 2 µM for both cell lines.{41830}  

 

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Description

An HDAC inhibitor (IC50s = 48, 32, and 41 µM for HDAC1, 4, and 6, respectively); increases acetylation of histone H4 and α-tubulin in HCT116 cells at 1-25 µM; inhibits the growth of a variety of cancer cell lines (EC50s = 1.1-9.1 µM); induces HIV-1 viral replication in OM10.1 and ACH-2 cells latently infected with HIV-1 at 0.4-1.6 µM with CC50s = 2 µM for both cell lines

Formal name: S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester, 2-methyl-propanethioic acid

Synonyms:  PTACH

Molecular weight: 390.6

CAS: 848354-66-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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