A water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC50 = 0.15 and 4.8 µM

NBQX (sodium salt) – 5 mg

Brand:
Cayman
CAS:
479347-86-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ionotropic glutamate receptors can be divided into three groups, depending on whether they are activated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, or N-methyl-D-aspartate (NMDA). NBQX is a water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC50 = 0.15 and 4.8 µM, respectively).{23787} It does not block the NMDA-sensitive glutamate receptor (IC50 = ≥ 90 µM).{23787} NBQX can be used in isolated neurons, tissues, or in vivo.{23788,23789,20019,23782}  

 

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Description

A water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC50 = 0.15 and 4.8 µM, respectively); does not block the NMDA-sensitive glutamate receptor (IC50 = ≥ 90 µM)

Formal name: 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide, disodium salt

Synonyms: 

Molecular weight: 380.2

CAS: 479347-86-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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