A small molecule CD4 mimetic; inhibits infection of MT-2 cells by laboratory-adapted HIV-1 IIIB

NBD-556 – 10 mg

Brand:
Cayman
CAS:
333353-44-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

NBD-556 is a small molecule CD4 mimetic that inhibits GP120 from interacting with CD4, preventing HIV-1 from entering CD4+ cells by binding to the GP120 exterior envelope glycoprotein.{34135} It inhibits infection of MT-2 cells by laboratory-adapted HIV-1 IIIB, MN, and V32 strains (IC50 = 6.5, 15.9, and 5.3 µM, respectively), an AZT-resistant (AZT-R) HIV-1 strain (IC50 = 58 µM), and various primary HIV-1 isolates (IC50s = 15-103 μM).  

 

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Description

A small molecule CD4 mimetic; inhibits infection of MT-2 cells by laboratory-adapted HIV-1 IIIB, MN, and V32 HIV strains (IC50 = 6.5, 15.9, and 5.3 µM, respectively), an AZT-resistant (AZT-R) HIV-1 strain (IC50 = 58 µM), and various primary HIV-1 isolates (IC50s = 15-103 μM)

Formal name: N1-(4-chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-ethanediamide

Synonyms: 

Molecular weight: 337.8

CAS: 333353-44-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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