A synthetic analog of Joro spider toxin that blocks GluR2-lacking

NASPM (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1049731-36-3
Storage:
-20
UN-No:
Non-Hazardous - /

NASPM is a synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors. The blocking effect of NASPM on these receptors is use and voltage-dependent. At -60 mV, NASPM can suppress current responses in kainate-induced type II neurons (which are typified by strong inward rectification and high permeability to Ca2+) with an IC50 value of 0.33 µM.{29984} However, at +40 mV, NASPM does not affect Ca2+-permeable AMPA receptors.{29984} NASPM has been shown to protect against ischemia-induced neuronal cell death by preventing influx of toxic levels of Ca2+ into injured neurons.{29985} This compound can be used to study the role of GluR2 subunits in calcium permeability of AMPA receptors.{29983,29985}  

 

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Description

A synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors (IC50 = 0.33 µM) at -60 mV but not at +40 mV; protects against ischemia-induced neuronal cell death by preventing influx of toxic levels of Ca2+ into injured neurons

Formal name: N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide, trihydrochloride

Synonyms:  1-Naphthylacetyl spermine

Molecular weight: 479.9

CAS: 1049731-36-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Neuroprotection|Ischemia

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