A plant growth inhibitor that can induce apoptosis-mediated cytotoxicity in human cancer cells but not in normal fibroblasts in vitro; regulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway by increasing GTPase RhoA activity

Narciclasine – 1 mg

Brand:
Cayman
CAS:
29477-83-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Narciclasine is a plant growth inhibitor that can be isolated from Narcissus bulbs. At 1 μM, it has been shown to induce apoptosis-mediated cytotoxicity in human cancer cells in vitro but not in normal fibroblasts.{32920} Narciclasine has been shown to regulate the Rho/Rho kinase/LIM kinase/cofilin signaling pathway by increasing GTPase RhoA activity, as well as inducing actin stress fiber formation in a RhoA-dependent manner.{32920}  

 

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Description

A plant growth inhibitor that can induce apoptosis-mediated cytotoxicity in human cancer cells but not in normal fibroblasts in vitro; regulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway by increasing GTPase RhoA activity, as well as inducing actin stress fiber formation in a RhoA-dependent manner

Formal name: (2S,3R,4S,4aR)-3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one

Synonyms:  (+)-Lycoricidinol|(+)-Narciclasine

Molecular weight: 307.3

CAS: 29477-83-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|GTPases||Research Area|Cell Biology|Cell Signaling|GTPases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Plant Biology|Plant Growth Regulators

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