Description
A potent 5-HT1B and 5-HT1D receptor agonist (IC50s = 9.4 and 1.5 nM, respectively, in a radioligand binding assay using human recombinant receptors); selective for 5-HT1B and 5-HT1D, lacking activity in rat aorta, guinea pig colon, and pig vena cava that highly express 5-HT2A, 5-HT4, and 5-HT7 receptors, respectively, at concentrations up to 10 μM; induces contraction of isolated human coronary arteries (EC50 = 170 nM); induces dose-dependent vasoconstriction of the carotid vascular bed in dogs when administered at doses ranging from 1-300 μg/kg; inhibits plasma protein extravasation induced by electrical stimulation of the trigeminal ganglion in the dura of anesthetized rats,
Formal name: N-methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide, monohydrochloride
Synonyms:
Molecular weight: 371.9
CAS: 143388-64-1
Purity: ≥95%
Formulation: A solid
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Neuroscience|Pain Research
