An ionophore antibiotic used in veterinary practice as a coccidiostat for gastrointestinal parasites; inhibits NF-κB signaling via inhibition of IκBα phosphorylation (IC50 = 3.2 µM) and stimulates TRAIL-mediated apoptosis in glioma cells via ER stress

Narasin (sodium salt) – 5 mg

Brand:
Cayman
CAS:
58331-17-2
Storage:
-20
UN-No:
Non-Hazardous - /

Narasin is an ionophore antibiotic isolated from certain Streptomyces sp. and used in veterinary practice as a coccidiostat for gastrointestinal parasites. It has also been shown to inhibit NF-κB signaling via inhibition of IκBα phosphorylation (IC50 = 3.2 µM) and to stimulate tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis in glioma cells via ER stress.{31081,31082}  

 

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Description

An ionophore antibiotic used in veterinary practice as a coccidiostat for gastrointestinal parasites; inhibits NF-κB signaling via inhibition of IκBα phosphorylation (IC50 = 3.2 µM) and stimulates TRAIL-mediated apoptosis in glioma cells via ER stress

Formal name: 4S-methyl-salinomycin, monosodium salt

Synonyms:  4-Methylsalinomycin|Monteban|Narasin A

Molecular weight: 787

CAS: 58331-17-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Ionophores||Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Parasitic Diseases

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