A fungal metabolite with diverse biological activities; active against S. aureus

Napyradiomycin A1 – 1 mg

Brand:
Cayman
CAS:
103106-24-7
Storage:
-20
UN-No:
Non-Hazardous - /

Napyradiomycin A1 is a fungal metabolite originally isolated from C. rubra and has diverse biological activities.{53567,53568} It is active against S. aureus, M. luteus, B. anthracis, C. bovis, and M. smegmatis (MICs = 1.56-12.5 µg/ml).{53567} Napyradiomycin A1 is an estrogen receptor antagonist (IC50 = 4.2 µM in rat uterine homogenates).{53568} It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 µM, respectively).{53569}  

 

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SKU: 29215 - 1 mg Category:

Description

A fungal metabolite with diverse biological activities; active against S. aureus, M. luteus, B. anthracis, C. bovis, and M. smegmatis (MICs = 1.56-12.5 µg/ml); estrogen receptor antagonist (IC50 = 4.2 µM in rat uterine homogenates); inhibits mitochondrial complex I and II in bovine heart homogenates (IC50s = 20 and 9.7 µM, respectively)

Formal name: (3R,4aR,10aS)-3,4a-dichloro-10a-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3,4,4a,10a-tetrahydro-6,8-dihydroxy-2,2-dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione

Synonyms: 

Molecular weight: 481.4

CAS: 103106-24-7

Purity: ≥70%

Formulation: A solid

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