A cell-permeable inhibitor of furin (IC50 = 12 μM); inhibits furin-mediated cleavage of the pro-form of MT1-MMP

Naphthofluorescein – 50 mg

Brand:
Cayman
CAS:
61419-02-1
Storage:
-20
UN-No:
Non-Hazardous - /

Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM).{16121} It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP.{16121} This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP.{16121} Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080.{16121} The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined.  

 

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SKU: 13055 - 50 mg Category:

Description

A cell-permeable inhibitor of furin (IC50 = 12 μM); inhibits furin-mediated cleavage of the pro-form of MT1-MMP, resulting in decreased levels of active MT1-MMP; inhibits the invasion of Matrigel by the human fibrosarcoma cell lines HT1080

Formal name: 3,11-dihydroxy-spiro[7H-dibenzo[c,h]xanthene-7,1′(3’H)-isobenzofuran]-3′-one

Synonyms:  CCG 8295

Molecular weight: 432.4

CAS: 61419-02-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Proteolysis

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