An inhibitor of cancer cell stemness; reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM); decreases protein and gene expression of various self-renewal and pro-survival markers in FaDu HNSCC cells; inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment (20 mg/kg per day); blocks formation of spleen and liver metastases in an HT29 ISMS model; reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models (40 mg/kg)

Napabucasin – 25 mg

Brand:
Cayman
CAS:
83280-65-3
Storage:
-20
UN-No:
Non-Hazardous - /

Napabucasin is an inhibitor of cancer cell stemness.{41559} It reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells. In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.{41560}  

 

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Description

An inhibitor of cancer cell stemness; reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM); decreases protein and gene expression of various self-renewal and pro-survival markers in FaDu HNSCC cells; inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment (20 mg/kg per day); blocks formation of spleen and liver metastases in an HT29 ISMS model; reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models (40 mg/kg)

Formal name: 2-acetyl-naphtho[2,3-b]furan-4,9-dione

Synonyms:  BBI 608

Molecular weight: 240.2

CAS: 83280-65-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cancer Stem Cell Research|Proliferation||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Transcription Factors

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