A polyether ionophore antibiotic; has insecticidal and antibacterial properties; blocks ZIKV entry into U2OS

Nanchangmycin – 5 mg

Brand:
Cayman
CAS:
65101-87-3
Storage:
-20
UN-No:
Non-Hazardous - /

Nanchangmycin is a polyether ionophore antibiotic produced by S. nanchangensis NS3226 that has insecticidal and in vitro antibacterial properties.{34684},{34685} Nanchangmycin exhibits antiviral properties against Zika virus (ZIKV) by blocking viral entry in vitro in a spectrum of cell types, including U2OS, human microvascular endothelial cells, and placental Jeg3 cells (IC50s = 100, 400, and 970 nM, respectively).{34686} Nanchangmycin also blocks ZIKV entry into primary cells, including extravillous trophoblasts, human primary uterine microvascular endothelial cells, human umbilical vein endothelial cells, and murine primary midbrain neuron-glia cultures.{34686} Efficacy of nanchangmycin extends to other viruses where it blocks entry into U2OS cells by West Nile, dengue, Sindbis, and chikungunya viruses.{34686}  

 

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Description

A polyether ionophore antibiotic; has insecticidal and antibacterial properties; blocks ZIKV entry into U2OS, human microvascular endothelial cells, and placental Jeg3 cells (IC50s = 100, 400, and 970 nM, respectively); blocks ZIKV entry into certain primary cells; effective against West Nile, dengue, Sindbis, and chikungunya viruses in U2OS cells

Formal name: (2S,4R,6E,8S)-8-[(2S,2’R,4’S,5R,5’S,7R,7’R,8R,9S,9’S,10’R)-9-hydroxy-2,4′,8,10′-tetramethyl-2′-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9′-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7′-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5-oxo-6-nonenoic acid, monosodium salt

Synonyms: 

Molecular weight: 889.1

CAS: 65101-87-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Ionophores||Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Viral Diseases|Chikungunya||Research Area|Infectious Disease|Viral Diseases|Dengue||Research Area|Infectious Disease|Viral Diseases|West Nile Virus||Research Area|Infectious Disease|Viral Diseases|Zika||Research Area|Toxicology|Environmental

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