Description
A polyether ionophore antibiotic; has insecticidal and antibacterial properties; blocks ZIKV entry into U2OS, human microvascular endothelial cells, and placental Jeg3 cells (IC50s = 100, 400, and 970 nM, respectively); blocks ZIKV entry into certain primary cells; effective against West Nile, dengue, Sindbis, and chikungunya viruses in U2OS cells
Formal name: (2S,4R,6E,8S)-8-[(2S,2’R,4’S,5R,5’S,7R,7’R,8R,9S,9’S,10’R)-9-hydroxy-2,4′,8,10′-tetramethyl-2′-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9′-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7′-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5-oxo-6-nonenoic acid, monosodium salt
Synonyms:
Molecular weight: 889.1
CAS: 65101-87-3
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics|Ionophores||Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Viral Diseases|Chikungunya||Research Area|Infectious Disease|Viral Diseases|Dengue||Research Area|Infectious Disease|Viral Diseases|West Nile Virus||Research Area|Infectious Disease|Viral Diseases|Zika||Research Area|Toxicology|Environmental
