A quinone bacterial metabolite; inhibits the growth of a variety of bacteria (MICs = P. falciparum (IC80 = 0.0033 µM); inhibits proliferation of HCT116

Nanaomycin A – 5 mg

Brand:
Cayman
CAS:
52934-83-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Nanaomycin A is a quinone bacterial metabolite originally isolated from Streptomyces that has antimicrobial activity.{45188} It inhibits the growth of a variety of bacteria (MICs = P. falciparum (IC80 = 0.033 µM).{45188,57310} Nanaomycin A is a selective DNA methyltransferase 3B (DNMT3B) inhibitor that inhibits proliferation of HCT116, A549, and HL-60 cancer cells (IC50s = 0.4, 4.1, and 0.8 µM, respectively).{57311} Nanaomycin A promotes the differentiation of human induced pluripotent stem (iPS) cells into hepatoblasts at the definitive endoderm cell-to-hepatoblast stage, but not the iPS cell-to-definitive endoderm cell stage, when used at a concentration of 1 µM.{57312}  

 

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SKU: 9001479 - 5 mg Category:

Description

A quinone bacterial metabolite; inhibits the growth of a variety of bacteria (MICs = P. falciparum (IC80 = 0.0033 µM); inhibits proliferation of HCT116, A549, and HL-60 cancer cells (IC50s = 0.4, 4.1, and 0.8 µM, respectively); promotes the differentiation of human iPS cells into hepatoblasts at the definitive endoderm cell-to-hepatoblast stage at 1 µM

Formal name: (1S,3R)-3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid

Synonyms:  Antibiotic OS 3966A|Nanafrocin|NNM-A|NSC 267461

Molecular weight: 302.3

CAS: 52934-83-5

Purity: ≥98%

Formulation: A solid

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