A 5-HT1A receptor mixed antagonist and partial agonist; inhibits radioligand binding to 5-HT1A sites in rat hippocampal membranes (Ki = 2 nM); decreases 5-carboxamidotryptamine-mediated inhibition of forskolin-induced adenylyl cyclase activity in guinea pig hippocampal membranes; antagonizes α1-ARs (pA2s = 9.47

NAN-190 – 25 mg

Brand:
Cayman
CAS:
115338-32-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

NAN-190 is a mixed antagonist and partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A.{45661} It inhibits radioligand binding to 5-HT1A sites in rat hippocampal membranes (Ki = 2 nM). NAN-190 decreases 5-carboxamidotryptamine-mediated inhibition of forskolin-induced adenylyl cyclase activity in guinea pig hippocampal membranes in a concentration-dependent manner, indicating partial agonist activity. NAN-190 also antagonizes α1-adrenergic receptors (α1-ARs; pA2s = 9.47, 9.02, and 9.99 in isolated rat tail artery, rabbit aorta, and rat aorta, respectively).{45662} In vivo, NAN-190 (1-300 μg/kg) decreases blood pressure, without modifying heart rate, in anesthetized rats. It inhibits phenylephrine-induced pressor responses in pithed rats. NAN-190 (5 mg/kg, i.p.) potentiates the circadian response to light in dark-adapted and entrained hamsters.{45663}  

 

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SKU: 29314 - 25 mg Category:

Description

A 5-HT1A receptor mixed antagonist and partial agonist; inhibits radioligand binding to 5-HT1A sites in rat hippocampal membranes (Ki = 2 nM); decreases 5-carboxamidotryptamine-mediated inhibition of forskolin-induced adenylyl cyclase activity in guinea pig hippocampal membranes; antagonizes α1-ARs (pA2s = 9.47, 9.02, and 9.99 in isolated rat tail artery, rabbit aorta, and rat aorta, respectively); decreases blood pressure in anesthetized rats from 1-300 μg/kg; inhibits phenylephrine-induced pressor responses in pithed rats; potentiates the circadian response to light in dark-adapted and entrained hamsters at 5 mg/kg, i.p.

Formal name: 2-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-1H-isoindole-1,3(2H)-dione, monohydrobromide

Synonyms: 

Molecular weight: 474.4

CAS: 115338-32-4

Purity: ≥95%

Formulation: A crystalline solid

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