A potent Nampt inhibitor (IC50 = 3.1 nM); selective for Nampt over a panel of >100 human kinases at 1 μM; inhibits NAD+ formation in and proliferation of HCT116 cells (IC50s = 1.8 and 8.9 nM

Nampt-IN-1 – 5 mg

Brand:
Cayman
CAS:
1698878-14-6
Storage:
-20
UN-No:
Non-Hazardous - /

Nampt-IN-1 is a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt; IC50 = 3.1 nM).{36930} It is selective for Nampt over a panel of greater than 100 human kinases at 1 μM. Nampt-IN-1 inhibits NAD+ formation in and proliferation of HCT116 cells (IC50s = 1.8 and 8.9 nM, respectively). It inhibits cell growth in a panel of cancer cell lines (IC50s = + formation in an A2780 ovarian carcinoma mouse xenograft model (ED50 = 2 mg/kg).  

 

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SKU: 26066 - 5 mg Category:

Description

A potent Nampt inhibitor (IC50 = 3.1 nM); selective for Nampt over a panel of >100 human kinases at 1 μM; inhibits NAD+ formation in and proliferation of HCT116 cells (IC50s = 1.8 and 8.9 nM, respectively); inhibits cell growth in a panel of cancer cell lines (IC50s = + formation in an A2780 ovarian carcinoma mouse xenograft model (ED50 = 2 mg/kg)

Formal name: 2-hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide

Synonyms:  LSN3154567|Nicotinamide Phosphoribosyltransferase-IN-1

Molecular weight: 419.5

CAS: 1698878-14-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Metabolism||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins

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