A first generation quinolone antibiotic; inhibits DNA gyrase and topoisomerase IV activity in Gram-negative bacteria with minimal bacteriostatic concentrations of 0.5-50.0 µg/ml

Nalidixic Acid – 10 g

Brand:
Cayman
CAS:
389-08-2
Storage:
4
UN-No:
Non-Hazardous - /

Nalidixic acid was the first quinolone-based antibiotic.{41042} It inhibits DNA gyrase and topoisomerase IV activity in Gram-negative bacteria with originally reported minimal bacteriostatic concentrations of 0.5-50.0 µg/ml.{41041,41042} Formulations containing nalidixic acid were used for the treatment of urinary tract infections.{41043} However, derivatives of nalidixic acid, comprising second, third, and fourth generation quinolones, have improved antibacterial actions and fewer adverse effects, so it is no longer used clinically.  

 

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Description

A first generation quinolone antibiotic; inhibits DNA gyrase and topoisomerase IV activity in Gram-negative bacteria with minimal bacteriostatic concentrations of 0.5-50.0 µg/ml

Formal name: 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Synonyms:  NSC 82174|WIN 18,320

Molecular weight: 232.2

CAS: 389-08-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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