A diterpenoid pyrone fungal metabolite with potassium channel inhibitory and antiviral activities; inhibits charybdotoxin binding to Jurkat cell membranes (IC50 = 3 µM); inhibits rubidium efflux from CHO cells expressing Kv1.3 (IC50 = 3.9 µM); depolarizes T cells in vitro (EC50 = 500 nM); inhibits HIV-1 integrase activity with IC50 values of 10 and 25 µM in coupled and strand transfer assays

Nalanthalide – 1 mg

Brand:
Cayman
CAS:
145603-76-5
Storage:
-20
UN-No:
Non-Hazardous - /

Nalanthalide is a diterpenoid pyrone fungal metabolite that has been found in Nalanthamala and has potassium channel inhibitory and antiviral activities.{53575} It inhibits binding of the potassium channel inhibitor charybdotoxin (Item No. 24115) to Jurkat cell membranes (IC50 = 3 µM) and inhibits rubidium efflux from CHO cells expressing the voltage-gated potassium (Kv) channel Kv1.3 (IC50 = 3.9 µM). Nalanthalide depolarizes T cells in vitro with an EC50 value of 500 nM. It also inhibits HIV-1 integrase activity with IC50 values of 10 and 25 µM in coupled and strand transfer assays, respectively.{37200}  

 

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SKU: 29724 - 1 mg Category:

Description

A diterpenoid pyrone fungal metabolite with potassium channel inhibitory and antiviral activities; inhibits charybdotoxin binding to Jurkat cell membranes (IC50 = 3 µM); inhibits rubidium efflux from CHO cells expressing Kv1.3 (IC50 = 3.9 µM); depolarizes T cells in vitro (EC50 = 500 nM); inhibits HIV-1 integrase activity with IC50 values of 10 and 25 µM in coupled and strand transfer assays, respectively

Formal name: 3-[[(1R,4aR,5S,6S,8aR)-6-(acetyloxy)decahydro-5,8a-dimethyl-2-methylene-5-(4-methyl-3-penten-1-yl)-1-naphthalenyl]methyl]-2-methoxy-5,6-dimethyl-4H-pyran-4-one

Synonyms:  (–)-Nalanthalide

Molecular weight: 484.7

CAS: 145603-76-5

Purity: ≥70%

Formulation: A solid

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