A GNRH agonist; a long-acting agent that

Nafarelin (acetate) – 500 µg

Brand:
Cayman
CAS:
76932-60-0
Storage:
-20
UN-No:
Non-Hazardous - /

Nafarelin is an agonist of gonadotropin-releasing hormone (GNRH).{40488,40489,40490} It is a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones. In vivo, nafarelin (0.5-2.0 μg/kg, s.c.) reduces plasma levels of luteinizing hormone and testosterone (Item Nos. 15645 | ISO60154) as well as testicular volume, sperm count, sperm motility, and duration of ejaculation in male dogs.{40488} Nafarelin (32 μg/animal per day) inhibits estrus in female beagle dogs.{40489} It also reduces the volume of endometrial tissue in a rat model of endometriosis.{40490} Formulations containing nafarelin have been used in the treatment of endometriosis and central precocious puberty.  

 

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Description

A GNRH agonist; a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones; reduces plasma levels of luteinizing hormone and testosterone as well as testicular volume, sperm count, sperm motility, and duration of ejaculation in male dogs when administered at a doses ranging from 0.5-2 μg/kg, s.c.; inhibits estrus in female beagle dogs; reduces the volume of endometrial tissue in a rat model of endometriosis

Formal name: 6-[3-(2-naphthalenyl)-D-alanine]-luteinizing hormone-releasing factor (swine) acetate

Synonyms: 

Molecular weight: 1,322.50

CAS: 76932-60-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Peptides||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Reproductive Biology

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