An NSAID and a prodrug form of 6-methoxy naphthalene acetic acid; reduces carrageenan-induced edema in rats from 5-45 mg/kg

Nabumetone – 1 g

Brand:
Cayman
CAS:
42924-53-8
Storage:
-20
UN-No:
Non-Hazardous - /

Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid (Item No. 70620).{32442} Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED50 = 11 mg/kg).{32441} It reduces phenyl-p-quinone-induced writhing in mice (ED50 = 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.  

 

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Description

An NSAID and a prodrug form of 6-methoxy naphthalene acetic acid; reduces carrageenan-induced edema in rats from 5-45 mg/kg, as well as UV-induced erythema in guinea pigs (ED50 = 11 mg/kg); reduces phenyl-p-quinone-induced writhing in mice (ED50 = 152 mg/kg); reduces endotoxin-induced pyresis in rabbits at 50, 100, and 200 mg/kg

Formal name: 4-(6-methoxy-2-naphthalenyl)-2-butanone

Synonyms:  BRL 14777

Molecular weight: 228.3

CAS: 42924-53-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Pain Research

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