An adenosine receptor agonist; selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM); decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM

N6-Cyclohexyladenosine – 25 mg

Brand:
Cayman
CAS:
36396-99-3
Storage:
-20
UN-No:
Non-Hazardous - /

N6-Cyclohexyladenosine is an adenosine receptor agonist.{48560} It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively).{48560} N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion.{52007} N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.).{52008}  

 

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Description

An adenosine receptor agonist; selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM); decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively); decreases heart rate and blood pressure in normotensive rats in vivo (EC25s = 2.4 and 4.2 μg/kg, respectively); induces sleep in rats via basal forebrain infusion at 100 μM; decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.)

Formal name: N-cyclohexyl-adenosine

Synonyms: 

Molecular weight: 349.4

CAS: 36396-99-3

Purity: ≥98%

Formulation: A crystalline solid

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