A cell permeable cAMP analog that selectively activates PKA over Epac1 and 2 (also known as RAPGEF3 and 4); binds the AI and AII subunits of PKA with pKi values of 4.0 and 3.8

N6-benzoyl-Cyclic AMP (sodium salt) – 10 mg

Brand:
Cayman
CAS:
1135306-29-4
Storage:
-20
UN-No:
Non-Hazardous - /

N6-benzoyl-Cyclic AMP (6-Bnz-cAMP) is a cell permeable cAMP analog that selectively activates PKA over exchange proteins activated by cAMP (Epac1 and 2, also known as RAPGEF3 and 4).{26217} It binds the AI and AII subunits of PKA with pKi values of 4.0 and 3.8, respectively, whereas it binds Epac1 with a pKi value of 1.3.{28118} 6-Bnz-cAMP stimulates the phosphorylation of the PKA substrate CREB but does not activate the Epac target Rap1.{28118} It can act synergistically with Epac-selective activators, such as 8-pCPT-2’-O-Me-cAMP (Item No. 17143).{30350,28118}  

 

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Description

A cell permeable cAMP analog that selectively activates PKA over Epac1 and 2 (also known as RAPGEF3 and 4); binds the AI and AII subunits of PKA with pKi values of 4.0 and 3.8, respectively, whereas it binds Epac1 with a pKi value of 1.3

Formal name: N-benzoyl-adenosine cyclic 3′,5′-(hydrogen phosphate), monosodium salt

Synonyms:  6-Bnz-cAMP

Molecular weight: 455.3

CAS: 1135306-29-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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