A diacetylated derivative of spermine that displays lower Km and higher Vmax values than spermine

N1,N12-Diacetylspermine (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
77928-71-3
Storage:
-20
UN-No:
Non-Hazardous - /

N1,N12-Acetylspermine is a diacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.{29261} Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes.{27553,29231} Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.{28930}  

 

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Description

A diacetylated derivative of spermine that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine; used as a biomarker for cancer detection

Formal name: N,N’-[1,4-butanediylbis(imino-3,1-propanediyl)]bis-acetamide, dihydrochloride

Synonyms:  BAS

Molecular weight: 359.3

CAS: 77928-71-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Research Area|Cancer

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