An activator of SERCA2A SUMOylation; activates SUMO-activating enzyme E1

N106 – 5 mg

Brand:
Cayman
CAS:
862974-25-2
Storage:
-20
UN-No:
Non-Hazardous - /

N106 is an activator of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2A (SERCA2A) SUMOylation.{56159} It activates SUMO-activating enzyme E1, which increases SUMOylation and the activity of SERCA2A in isolated adult rat cardiomyocytes when used at concentrations ranging from 0.1 to 1 µM. N106 increases contractility in the same cells. In vivo, N106 (10 mg/kg) increases cardiac SERCA2A SUMOylation and contractility in a mouse model of pressure overload-induced heart failure.  

 

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SKU: 30952 - 5 mg Category:

Description

An activator of SERCA2A SUMOylation; activates SUMO-activating enzyme E1, which increases SUMOylation and the activity of SERCA2A in isolated adult rat cardiomyocytes from 0.1-1 µM; increases contractility in the same cells; increases cardiac SERCA2A SUMOylation and contractility in a mouse model of pressure overload-induced heart failure at 10 mg/kg

Formal name: 4-methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-2-benzothiazolamine

Synonyms: 

Molecular weight: 354.4

CAS: 862974-25-2

Purity: ≥98%

Formulation: A solid

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