A selective

N-Oleoyl Dopamine – 100 mg

Brand:
Cayman
CAS:
105955-11-1
Storage:
-20
UN-No:
Non-Hazardous - /

N-Oleoyl dopamine (ODA) is a selective, endogenous vanilloid receptor 1 (VR1) agonist isolated from bovine brain.{11117} Structurally, it is the amide of oleic acid and dopamine and is therefore a “hybrid” analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. ODA binds to the human recombinant VR1 with a Ki of 36 nM making it equipotent to capsaicin and slightly more potent than N-arachidonoyl dopamine in this assay.{11117} It causes hyperalgesia and nocifensive behavior that is blocked by the VR1 antagonist iodo-resiniferatoxin. ODA is selective for VR1 based on observations that it has weak affinity for the rat CB1 receptor (Ki of 1.6 µM) and is a very weak inhibitor of FAAH. ODA is also a potent inhibitor of 5-lipoxygenase from rat basophilic leukemia-1 (RBL-1) cells, with a IC50 of 7.5 nM.{11036,11037}  

 

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Description

A selective, endogenous TRPV1 agonist that is a “hybrid” analog, which incorporates components of both the AEA-like and dopamine neurotransmitter pathways; binds to the human recombinant TRPV1 (Ki = 36 nM) with equipotency to that of capsaicin and slightly more potency than that of N-arachidonoyl dopamine; causes hyperalgesia and nocifensive behavior that is blocked by the TRPV1 antagonist iodo-resiniferatoxin; has weak affinity for the rat CB1 receptor (Ki = 1.6 µM) and is a very weak inhibitor of FAAH; inhibits 5-LO from rat RBL-1 cells (IC50 = 7.5 nM)

Formal name: N-[2-(3,4-dihydroxyphenyl)ethyl]-9Z-octadecenamide

Synonyms:  ODA

Molecular weight: 417.6

CAS: 105955-11-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Amides||Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids||Research Area|Neuroscience|Pain Research

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