A selective and potent activator of PPARα with an EC50 value of 100 nM; induces satiety

N-Octadecyl-N’-propyl-sulfamide – 5 mg

Brand:
Cayman
CAS:
925891-74-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Peroxisome proliferator-activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARα, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally.{9302,11423} N-Octadecyl-N’-propyl-sulfamide is an analog of OEA with selective binding affinity for PPARα. It is a more potent activator of PPARα, exhibiting an EC50 value of 100 nM, compared to OEA, which exhibits an EC50 value of 120 nM.{14617,11423} At a dose of 1 mg/kg for 8-11 days, N-octadecyl-N’-propyl-sulfamide induces satiety, thereby decreasing food-intake, body weight, and plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats.{14617}  

 

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SKU: 10009661 - 5 mg Category:

Description

A selective and potent activator of PPARα with an EC50 value of 100 nM; induces satiety, decreases food-intake, reduces body weight, and lowers plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats

Formal name: N-octadecyl-N’-propyl-sulfamide

Synonyms: 

Molecular weight: 390.7

CAS: 925891-74-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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