An inhibitor of α-glucosidase and α-1

N-Nonyldeoxynojirimycin – 25 mg

Brand:
Cayman
CAS:
81117-35-3
Storage:
-20
UN-No:
Non-Hazardous - /

N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid α-glucosidase and α-1,6-glucosidase (IC50s = 0.42 and 8.4 μM, respectively).{52246} NN-DNJ (250 mg/kg per day) increases hepatic glycogen levels in fasted mice and gastrocnemius muscle glycogen levels in both fasted and fed mice. It is a chemical chaperone of β-glucosidase that increases activity by 1.65-fold in patient-derived fibroblasts homozygous for the N370S Gaucher disease mutation when added to the culture medium at a concentration of 5 μM, but inhibits β-glucosidase activity at concentrations greater than 60 μM.{52247} NN-DNJ inhibits viral replication in BHK-21 cells infected with Japanese encephalitis virus (JEV) or dengue virus serotype 2 (DEN-2) and has protective effects in a mouse model of lethal JEV challenge when administered at a dose of 200 mg/kg per day.{52248}  

 

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SKU: 29698 - 25 mg Category:

Description

An inhibitor of α-glucosidase and α-1,6-glucosidase (IC50s = 0.42 and 8.4 μM, respectively); increases hepatic glycogen levels in fasted mice and gastrocnemius muscle glycogen levels in both fasted and fed mice at 250 mg/kg per day; increases β-glucosidase activity by 1.65-fold in patient-derived fibroblasts homozygous for the N370S Gaucher disease mutation when added to the culture medium at 5 μM, but inhibits β-glucosidase activity at >60 μM; DNJ inhibits viral replication in BHK-21 cells JEV or DEN-2); has protective effects in a mouse model of lethal JEV challenge at 200 mg/kg per day

Formal name: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol

Synonyms:  NN-DNJ|Nonyl-DNJ

Molecular weight: 289.4

CAS: 81117-35-3

Purity: ≥98%

Formulation: A solid

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