A ferrochelatase inhibitor and turn-on biosensor for DNA; inhibits ferrochelatase in mouse liver mitochondria in vitro; inhibits ferrochelatase in mice at 80 nmol

N-methyl Mesoporphyrin IX – 1 mg

Brand:
Cayman
CAS:
142234-85-3
Storage:
-20
UN-No:
Non-Hazardous - /

N-methyl Mesoporphyrin IX is a transition state analog of porphyrin and an inhibitor of ferrochelatase.{48312} It inhibits ferrochelatase in mouse liver mitochondria in vitro and in vivo, leading to an accumulation of porphyrin in isolated liver mitochondria following administration of an intravenous dose of 80 nmol. N-methyl Mesoporphyrin IX has been used as a turn-on biosensor for target DNA sequences when used in complex with a G-quadruplex-forming sequence fused to a DNA sequence complementary to the target sequence.{48313} It has also been used to detect amyloid-β (1-40) (Aβ40) fibrils in vitro and in live PC12 cells overexpressing Aβ.{48314} N-methyl Mesoporphyrin displays excitation/emission maxima of 399/610 nm, respectively.{48315}  

 

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SKU: 27210 - 1 mg Category:

Description

A ferrochelatase inhibitor and turn-on biosensor for DNA; inhibits ferrochelatase in mouse liver mitochondria in vitro; inhibits ferrochelatase in mice at 80 nmol, i.v. leading to porphyrin accumulation in isolated liver mitochondria; has been used as a turn-on biosensor for target DNA sequences when used in complex with a G-quadruplex-forming sequence fused to a DNA sequence complementary to the target sequence; ex/em = 399/610, respectively

Formal name: 8,13-diethyl-3,7,12,17,23-pentamethyl-21H,23H-porphine-2,18-dipropanoic acid

Synonyms: 

Molecular weight: 580.7

CAS: 142234-85-3

Purity: ≥95% (mixture of isomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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