An active metabolite of bendamustine; formed via CYP1A2 metabolism; inhibits proliferation of PBLs (IC50 = 45 µM) and SU-DHL-1

N-desmethyl Bendamustine – 1 mg

Brand:
Cayman
CAS:
41515-13-3
Storage:
-20
UN-No:
Non-Hazardous - /

N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine (Item No. 23693).{49043} N-desmethyl Bendamustine is formed through demethylation of the benzimidazole ring in bendamustine by the cytochrome P450 (CYP) isoform CYP1A2. It inhibits proliferation of non-cancerous peripheral blood leukocytes (PBLs; IC50 = 45 µM) and SU-DHL-1, SU-DHL-9, and Daudi lymphoma cells (IC50s = 270, 170, and 120 µM, respectively).  

 

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SKU: 27171 - 1 mg Category:

Description

An active metabolite of bendamustine; formed via CYP1A2 metabolism; inhibits proliferation of PBLs (IC50 = 45 µM) and SU-DHL-1, SU-DHL-9, and Daudi lymphoma cells (IC50s = 270, 170, 120 µM, respectively)

Formal name: 6-[bis(2-chloroethyl)amino]-1H-benzimidazole-2-butanoic acid

Synonyms:  nor-Bendamustine

Molecular weight: 344.2

CAS: 41515-13-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|DNA Alkylating Agents||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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