An active metabolite of sunitinib; formed when sunitinib undergoes N-de-ethylation by CYP3A4; is pharmacologically active having similar inhibitory activity to sunitinib

N-desethyl Sunitinib – 10 mg

Brand:
Cayman
CAS:
356068-97-8
Storage:
-20
UN-No:
Non-Hazardous - /

N-desethyl Sunitinib is an active metabolite of sunitinib (Item No. 13159), a small molecule, multi-targeted receptor tyrosine kinase inhibitor.{17043,40284} N-desethyl Sunitinib is formed when sunitinib undergoes N-de-ethylation by the cytochrome P450 (CYP) isomer CYP3A4.{40284} N-desethyl Sunitinib is pharmacologically active having similar inhibitory activity to sunitinib.  

 

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Description

An active metabolite of sunitinib; formed when sunitinib undergoes N-de-ethylation by CYP3A4; is pharmacologically active having similar inhibitory activity to sunitinib

Formal name: N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl- 1H-pyrrole-3-carboxamide

Synonyms:  SU 12662

Molecular weight: 370.4

CAS: 356068-97-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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