An endocannabinoid analog that does not bind to CB1

N-Arachidonoyl-L-Serine – 5 mg

Brand:
Cayman
CAS:
187224-29-9
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature.{9213} N-Arachidonoyl-L-serine (ARA-S) is one such recently isolated endocannabinoid with an unusual activity profile. ARA-S does not bind to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors or vanilloid receptor 1 (VR1). Like cannabidiol, ARA-S (5 mg/kg) antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model.{11984} However, similar to Abn-CBD, ARA-S relaxes isolated rat mesenteric arteries and abdominal aorta as well as increases phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in HUVEC.{14066} The precise mechanisms of action by ARA-S and Abn-DBD in various vascular preparations appears to be different and requires further investigation.  

 

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SKU: 10005455 - 5 mg Category:

Description

An endocannabinoid analog that does not bind to CB1, CB2, or TRPV1; at 5 mg/kg antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model; relaxes isolated rat mesenteric arteries and abdominal aorta, and increases the phosphorylation of Akt and MAPK in HUVEC

Formal name: N-[1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl]-L-serine

Synonyms:  ARA-S

Molecular weight: 391.5

CAS: 187224-29-9

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Amides||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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