An arachidonoyl amino acid and CB1 receptor agonist (Ki = 250 nM in rat brain membranes

N-Arachidonoyl Dopamine – 5 mg

Brand:
Cayman
CAS:
199875-69-9
Storage:
-20
UN-No:
De Minimis - 1170 / 3

N-Arachidonoyl dopamine (NADA) is an arachidonoyl amino acid and cannabinoid (CB) receptor 1 agonist (Ki = 250 nM in rat brain membranes, which highly express CB1 receptors).{9213} It is selective for CB1 over CB2 receptors (Ki = >12,000 nM in rat spleen membranes, which highly express CB2 receptors). NADA induces intracellular calcium mobilization in N18TG2 neuroblastoma cells (EC50 = 0.7 µM). It inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 0.25 µM), an effect that can be reversed by the CB1 receptor antagonist SR141716A (rimonabant; Item No. 9000484). NADA (10 mg/kg) induces hypothermia, catalepsy, hypolocomotion, and analgesia in mice.  

 

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SKU: 90057 - 5 mg Category:

Description

An arachidonoyl amino acid and CB1 receptor agonist (Ki = 250 nM in rat brain membranes, which highly express CB1 receptors); selective for CB1 over CB2 receptors (Ki = >12,000 nM in rat spleen membranes, which highly express CB2 receptors); induces intracellular calcium mobilization in N18TG2 neuroblastoma cells (EC50 = 0.7 µM); inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 0.25 µM); induces hypothermia, catalepsy, hypolocomotion, and analgesia in mice at 10 mg/kg

Formal name: N-[2-(3,4-dihydroxyphenyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide

Synonyms:  NADA

Molecular weight: 439.6

CAS: 199875-69-9

Purity: ≥98%

Formulation: A solution in ethanol

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