A non-ribotoxic form of puromycin; formed in puromycin-resistant S. alboniger that endogenously express puromycin-acetyltransferase

N-Acetylpuromycin – 10 mg

Brand:
Cayman
CAS:
22852-13-7
Storage:
-20
UN-No:
Non-Hazardous - /

N-Acetylpuromycin is a non-ribotoxic form of the antibiotic puromycin (Item No. 13884) that is formed in puromycin-resistant S. alboniger that endogenously express puromycin-acetyltransferase.{37780} In AD293(Pr) cells that express puromycin-N-acetyltransferase, the enzyme responsible for the biosynthesis of N-acetylpuromycin, puromycin application induces downregulation of the negative regulators of TGF-β signalling SnoN and Ski without activating MAPK or inhibition of protein synthesis.{37781}  

 

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Description

A non-ribotoxic form of puromycin; formed in puromycin-resistant S. alboniger that endogenously express puromycin-acetyltransferase

Formal name: 3′-[[(2S)-2-(acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-adenosine

Synonyms: 

Molecular weight: 513.6

CAS: 22852-13-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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