N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat

N-acetyl Leukotriene E4 – 50 µg

Brand:
Cayman
CAS:
80115-95-3
Storage:
-80
UN-No:
De Minimis - 1170 / 3

N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans.{544,546} N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent.{546} In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).{307}  

 

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Description

N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans.{544,546} N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent.{546} In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).{307}

Formal name: 5S-hydroxy-6R-(S-(N-acetyl)cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid

Synonyms:  N-acetyl LTE4

Molecular weight: 481.6

CAS: 80115-95-3

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Leukotrienes||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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