A chelating agent; inhibits the binding of methyl mercury to isolated human erythrocytes by 50% and removes 50% of methyl mercury ions from methyl mercury-loaded blood cells at 1 mM; reduces the biological half-life of mercury and decreases liver

N-Acetyl-DL-penicillamine – 1 g

Brand:
Cayman
CAS:
59-53-0
Storage:
-20
UN-No:
Non-Hazardous - /

N-Acetyl-DL-penicillamine is a chelating agent.{45968,45972,45969} It inhibits the binding of methyl mercury to isolated human erythrocytes by 50% and removes 50% of methyl mercury ions from methyl mercury-loaded blood cells when used at a concentration of 1 mM.{45968,45972} N-Acetyl-DL-penicillamine (3 mmol/kg per day, p.o.) reduces the biological half-life of mercury and decreases liver, kidney, brain, and blood mercury levels, as well as increases urinary excretion of mercury in a concentration-dependent manner, in mice when administered following injection of methyl mercuric chloride. It decreases mercuric chloride-induced mortality in mice when administered orally at a dose of 1.6 mmol/kg.{45969} N-Acetyl-DL-penicillamine is also an analog of SNAP (Item No. 82250) that does not generate nitric oxide and has been used as a negative control in experiments using SNAP.{45970,45971}  

 

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SKU: 10010404 - 1 g Category:

Description

A chelating agent; inhibits the binding of methyl mercury to isolated human erythrocytes by 50% and removes 50% of methyl mercury ions from methyl mercury-loaded blood cells at 1 mM; reduces the biological half-life of mercury and decreases liver, kidney, brain, and blood mercury levels, as well as increases urinary excretion of mercury in a concentration-dependent manner, in mice at 3 mmol/kg per day, p.o. following injection of methyl mercuric chloride; decreases mercuric chloride-induced mortality in mice at 1.6 mmol/kg, p.o.; has been used as a negative control in experiments using SNAP

Formal name: N-acetyl-3-mercapto-valine

Synonyms:  NAPA|NSC 28039|NSC 92752

Molecular weight: 191.2

CAS: 59-53-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Metal Chelators||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen||Research Area|Toxicology

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