A monosaccharide derivative of glucose that is released by the action of O-GlcNAcase

N-acetyl-D-Glucosamine – 5 g

Brand:
Cayman
CAS:
7512-17-6
Storage:
-20
UN-No:
Non-Hazardous - /

N-acetyl-D-Glucosamine (GlcNAc) is a monosaccharide derivative of glucose. It is released by the action of O-GlcNAcase, in mammalian systems from proteins that have been post-translationally modified with O-GlcNAc. Levels of O-GlcNAcylation proteins from Alzheimer’s disease brain extracts are decreased as compared to that in controls, suggesting that release of GlcNAc may contribute to pathogenesis.{16842} In E. coli, GlcNAc induces the expression of multidrug exporter genes, indicating that this sugar can alter gene expression.{16842} GlcNAc is also the monomeric unit of chitin, which is found in fungi and many invertebrates, including crustaceans, insects, and nematodes. For this reason, chemicals that inhibit the incorporation of GlcNAc into chitin are cytotoxic to these organisms.  

 

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Description

A monosaccharide derivative of glucose that is released by the action of O-GlcNAcase, in mammalian systems, from proteins that have been post-translationally modified with O-GlcNAc; also is the monomeric unit of chitin, which is found in fungi and many inverebrates, including crustaceans, insects, and nematodes

Formal name: 2-(acetylamino)-2-deoxy-D-glucose

Synonyms:  GlcNAc|Marine Sweet|NAG|NSC 524344

Molecular weight: 221.2

CAS: 7512-17-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Carbohydrates||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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