A metabolite of 5-ASA and sulfasalazine; reduces IFN-γ binding to colonic epithelial cells by 24% at 10 mM; scavenges DPPH radicals in a cell-free assay; inhibits hydroxy radical-stimulated DNA base hydroxylation; urinary levels have been used as a marker of 5-ASA adherence in patients with inflammatory bowel disease

N-acetyl-5-Aminosalicylic Acid – 50 mg

Brand:
Cayman
CAS:
51-59-2
Storage:
-20
UN-No:
Non-Hazardous - /

N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid (5-ASA; Item No. 70265) and its prodrug form, sulfasalazine (Item No. 15025).{42753,8455} It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases.{42754} It reduces IFN-γ binding to colonic epithelial cells by 24% when used at a concentration of 10 mM.{42756} N-acetyl-5-Aminosalicylic acid (100 µM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by hydroxy radicals.{42753,42755} Unlike sulfasalazine, N-acetyl-5-aminosalicylic acid does not inhibit 15-hydroxy prostaglandin dehydrogenase (PGDH).{8455} Urinary levels of N-acetyl-5-aminosalicylic acid have been used as a marker of 5-ASA adherence in patients with inflammatory bowel disease.{42757}  

 

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Description

A metabolite of 5-ASA and sulfasalazine; reduces IFN-γ binding to colonic epithelial cells by 24% at 10 mM; scavenges DPPH radicals in a cell-free assay; inhibits hydroxy radical-stimulated DNA base hydroxylation; urinary levels have been used as a marker of 5-ASA adherence in patients with inflammatory bowel disease

Formal name: 5-(acetylamino)-2-hydroxy-benzoic acid

Synonyms:  Acetylmesalazine|N-acetyl Mesalamine|N-acetyl-ASA|NSC 54183|Salicytamide

Molecular weight: 195.2

CAS: 51-59-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Gastric Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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