An inhibitor of human neuraminidases (IC50s = 143

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid – 1 mg

Brand:
Cayman
CAS:
24967-27-9
Storage:
-20
UN-No:
Non-Hazardous - /

N-acetyl-2,3-dehydro-2-Deoxyneuraminic acid (DANA) is an inhibitor of human neuraminidases (sialidases) NEU1-4 (IC50s = 143, 43, 61, and 74 μM, respectively).{38566} In vivo, DANA (30 μl of a 5 mM solution) reduces latency to first seizure and increases seizure duration in a rat model of potassium-induced seizures.{38567}  

 

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Description

An inhibitor of human neuraminidases (IC50s = 143, 43, 61, and 74 μM, for NEU 1, 2, 3, and 4, respectively); reduces latency to first seizure and increases seizure duration in a rat model of potassium-induced seizures,

Formal name: 5-(acetylamino)-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid

Synonyms:  DANA

Molecular weight: 291.3

CAS: 24967-27-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Seizure Disorders

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